Which of the following is not a sign of an overdose?

Excessive energy is not a sign of an overdose because it typically indicates a heightened state of alertness or activity, which contrasts sharply with the symptoms associated with overdose situations. In cases of overdose, individuals often exhibit decreased levels of consciousness, impaired cognitive function, and suppressed physical responses.

In contrast, confusion, difficulty breathing, and unresponsiveness are commonly observed signs of an overdose, especially with substances that depress the central nervous system. Confusion may point to impaired mental function, difficulty breathing indicates possible respiratory distress, and unresponsiveness can signify a critical state where the individual may not react to external stimuli, all of which are serious indicators of overdose and require immediate medical attention.